atlas of blood cells & blood diseases
 
atlas on integrated diagnosis
in hematology

T. Vallespí & L. García-Alonso
Project directed by Dra. Teresa Vallespí and Dr. Luis García - www.atlasbloodcells.es © 2012 | Legal notice

PHYSYOLOGY (A)




BENIGN and CONGENITAL BLOOD DISORDERS (B)



MALIGNANT BLOOD DISORDERS (C) (WHO 2008, modified)


OTHER DISEASES
DIAGNOSED IN BLOOD
or IN BONE MARROW (D)

PHYSYOLOGY (A)
Laboratory assessment | Special studies | Cytogenetic studies | Comparative Genomic hybridization

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Comparative Genomic Hybridization (CGH)
CGH and FISH is a method for analyzing genomic DNA for unbalanced genetic alterations. Genomic DNA from the test sample (e.g., tumor cells) is labeled (e.g., green) and mixed with normal genomic DNA labeled another color (e.g., red) and the mixture is hybridized (FISH) to a normal human metaphase spread or other reference standard. Regions of imbalance (increased or decreased copy number) in the tumor are located or mapped relative to the normal metaphase chromosomes as increases or decreases in the green to orange/red fluorescence ratio. Some examples of CGH: 3q+10p-, 11q+, 15q+.

Author: Jesús Mª Hernández y Juan Luis García
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